Preeclampsia, 2016

Injured uterine arterioles and myometrium stain browns for purinergic (P2X3)”stretch” receptors. Increasing blood flow during pregnancy stimulates these receptors activating a uterorenal reflex that causes a vascular shunt between the renal cortex and medulla. This shunt, in turn, activates the renin-angiotensin system causing hypertension and proteinuria.