Preeclampsia, 2016

Injured uterine arterioles and myometrium stains brown for purinergic (P2X3)”stretch” receptors (above). Increasing blood flow during pregnancy stimulates these receptors activating Nerves between the uterus and the kidneys that, in turn, diverts blood from the renal cortex to the renal medulla. Reduced blood flow activates the renin-angiotensin system causing hypertension and proteinuria.

Delivering the baby reduces the “stretch” and reverses the process.

Early-onset PE (<34 weeks) results from stretching P2X3 receptors in
injured arterioles (a) whilst late-onset PE (>34weeks) results from stretching similar receptors in injured myometrium (b).